Ncbs is pleased to welcome Arati Ramesh as faculty.

Arati Ramesh obtained her Ph.D. in Biochemistry and Biophysics from the lab of Dr. James C. Sacchettini at Texas A&M University. Here she used structural approaches to understand protein-RNA/DNA interactions in pathogenic bacteria. For her postdoctoral training, Arati joined the lab of Dr. Wade C. Winkler in the Department of Biochemistry at UT Southwestern Medical Center, Dallas. In the Winkler lab she made important contributions towards understanding how riboswitch RNAs directly sense cellular signals to regulate genes, ultimately controlling processes such as metal homeostasis and metabolism in bacteria. Her work reveals new mechanisms wherein signal-sensing riboswitches and small structured RNAs collaborate with proteins, forming complex regulatory networks that control biological processes.

At NCBS, Arati's lab aims to understand how riboswitches and small RNAs function in concert with RNA-binding proteins in pathogenic bacteria. Using a combination of X-ray crystallography, RNA and protein biochemistry, bioinformatics and microbiology her lab seeks to discover new RNA-based networks, determine their regulatory mechanisms and identify their role in bacterial biology. The added goal of her lab's research is to exploit these interactions to develop genetic tools.

Email: Arati@ncbs.res.in