One of the most important processes required for the sustenance of cells is a function called endocytosis. Among other functions, endocytosis allows cells to engulf proteins and food or fluid matter from its surroundings. Endocytosis can occur through several pathways - the most well-characterized of these is mediated through a 'coat protein' (clathrin) and others, that do not require clathrin are collectively termed clathrin-independent processes. The clathrin-dependent endocytic pathway requires this 'coat protein' to induce the formation of 'buds' on the plasma membrane of cells which eventually 'pinch off' into vesicles. Clathrin-independent pathways, on the other hand, do not use clathrin in forming pits or buds prior to endocytosis and use other accessory proteins.
With contributions from the Udgaonkar lab and Ipsita Herlekar.
The Protein Folding Lab at NCBS has turned 25. Jayant Udgaonkar's lab is one of NCBS's oldest laboratories. In 1990, Udgaonkar was the first scientist from outside TIFR to be recruited to the nascent NCBS. It would be two years before all the formal approvals for NCBS came through, but in the meantime Udgaonkar's lab started work on the mechanism of protein folding, which it continues even today. The group had its beginnings at TIFR Mumbai, before moving to Bangalore.
Living cells aren't self-sufficient; they need to interact with their environment in order to survive. But these interactions are extensively controlled by the barrier called the cell membrane, a dynamic entity made up of lipids and proteins. Molecules are constantly passing in and out of the cell through the semi-permeable cell membrane, their movement often orchestrated by different forces and membrane components. This was the level of understanding of this barrier's structure and function, posited by the 'fluid mosaic' model developed by Singer and Nicholson in 1972. Little was known then about minute details of the driving forces at the nano scale.
The campus will soon be hosting “the Black Label Movement”, a dance company led by Professor Carl Flink in collaboration with Professor David Odde (Department of Biomedical Engineering), both from the University of Minnesota. A series of events have been planned in the city as well as two events on campus.
NCBS announces its 5th annual science journalism workshop, which will be held on campus from June 8 to June 20, 2015.The workshop’s main objective is to impart the basic skills necessary for communicating science to the lay person via the written word.
Prof. Satyajit Mayor, Director, National Centre for Biological Sciences (NCBS) and Institute for Stem Cell Biology and Regenerative Medicine (inStem), has been elected a Foreign Associate of the US National Academy of Sciences (NAS).
The phrase "intellectual property" is often used in the Indian media as synonymous with "patents". In fact, patents are only one form of intellectual property. Other forms of intellectual property include trademarks, copyright, design rights, plant variety protection, etc. Of these, trademarks are used in business for the purpose of distinguishing the goods or services of one person from those of others.