Team Talk

Saturday, August 14th, 2010

An air of excitement and apprehension filled LH1 on the 5th and 6th of August 2010. The defense of their theses was the final hurdle between students of the 2008-2010 Masters in Wildlife Biology and Conservation Program, and their graduation. A rousing introductory speech and introduction of the ‘dreaded’ examiners on Day 1 was followed by presentation of studies about how different saç ekimi species use the habitats they live in.

Saturday, August 7th, 2010

When writing a grant proposal, scientists often promote the potential of the research to improve the quality of life of the common man. And when a proposal is focused on cancer treatment, claims of some broad social benefit are generally well-received, with cancer sadly being an increasingly common part of our unhealthy lifestyles. But do we as researchers actually understand the problems that clinicians face when they begin to treat a cancer patient or even when they need to diagnose a suspected case of cancer? If we do not understand the decision-making process of the clinician, our laboratory experiments may be uninformed and misdirected. And conversely, unless clinicians are aware of ongoing research efforts and ideas, their treatment regimens will not conform to "best possible practice".

Saturday, July 24th, 2010

A group of students in the MSc. Wildlife and Conservation programme in NCBS recently made a short (7-min) documentary film about a place that is host to a unique but fast disappearing population of birds. It is 50 km from Bangalore, yet hardly any of us know about the dangers faced by its wildlife. This is the story of how and why the documentary was made and what the students learned from the experience. (Watch the documentary, Awaiting Death on YouTube here.)

Sunday, May 2nd, 2010

NCBS prides itself on the interdisciplinarity of its biology. Investigations in more traditional areas are enriched by contributions from researchers with strengths in physics, mathematics, informatics, chemistry and nanotechnology. The benefits of such cross-fertilisation were exemplified last year when a DNA-based pH probe developed by Yamuna Krishnan’s nanobiology team was quickly shown to actually work in living cells in collaboration with Jitu Mayor’s team. (see Nature News article). 

Monday, April 19th, 2010

Science seems to attract a naturally cautious breed. When you actually start doing research, however, you soon realise that an entirely new level of cautiousness is called for. The perils of "confirmation bias", Murphy’s Law, and the sheer technological complexity of even a routine experiment can quickly humble the researcher and drive home the value of taking every aspect of a project very, very seriously. Nature does not yield her secrets easily.

Scientists learn the many aspects of "taking things seriously" largely by trial and error, or via the informal advice of their colleagues. Last week however thirty NCBS researchers had the benefit of a more systematic approach to education in this area: a 3-day workshop that provided an introduction to a consolidated body of knowledge called Good Laboratory Practice (GLP).
Saturday, March 6th, 2010
Microscopists always want to look more closely, but up until quite recently biologists have been drastically restricted in what they can study with the light microscope. For a microscope used in traditional fashion, the laws of physics dictate that two objects need to be more than 200nm apart (i.e. about half the wavength of the illuminating light) or their images will blur together. This is fine for viewing cells – for example, a red blood cell is about 7000nm in diameter - but for many of a cell's most interesting features the so-called “diffraction barrier” does pose problems. The plasma membrane for example is about 7 to 10 nm thick, and cannot be resolved with light microscopy. These finer structures can be examined with electron microscopy, where the resolving power increases to less than a nanometre, but with this approach biologists cannot take advantage of a wide range of powerful specimen preparation techniques, most particularly the targeting of structures with fluorescent probes.
Saturday, February 13th, 2010

This week on February 15 and 16 NCBS will host a meeting, “Learning about memory: cells, circuits and behaviour”, that brings together the world’s leading researchers on the neurobiological basis of memory. The six speakers, each of whom will give one talk each day, span the field, not only in terms of its scope – from molecular mechanisms right up to network dynamics – but also its entire history.

Tim Bliss, the first speaker, was the co-author, with Terje Lømo, of the 1973 paper that gave the initial detailed account of “long-term potentiation” (LTP) a phenomenom that provided, for the first time, evidence of a possible cellular foundation for memory. LTP describes a form of enhanced and enduring connectivity between neurons that develops if there is frequent electrochemical crosstalk across their junction (the synapse). Thus repeated experiences have a greater possibility of leaving a neural trace in our brains, and so, for better or worse, we are at least partly the products of our own individual history.

Saturday, February 6th, 2010

Every August finds the NCBS campus brightened by its new students, and particularly so each second summer with the arrival of a small but particularly committed cohort - the fifteen enrollees of the Masters Course in Wildlife Biology and Conservation. The fourth batch, who will be the graduates of 2012, are being selected right now, to emerge as the success stories of a tough filtering process that sifts through about 400 candidates each time. And the difficulty of the process lies not just in the number of applicants but in their quality. Many of the wildlife students are giving up already successful careers as doctors, vets and engineers to switch to a profession where the promise of substantial financial reward can never be mistaken as a major lure.

Saturday, January 23rd, 2010

Starting Saturday, January 23 the third Molecular Motors, Tracks and Transport (M2T2) international workshop will run for six days in Pondicherry, India.

In mechanical devices, directed movement typically depends upon some type of motor. Living systems also have their motors, used to drive the organism as a whole, or parts of its body or even the movement of structures within the cell itself. Intracellular movements depend upon molecular motors that use sophisticated intramolecular amplification mechanisms to take nanometre steps along protein tracks laid out in linear fashion in the cytoplasm.

Saturday, January 16th, 2010

For many a researcher at NCBS subjecting their system to microscopic scrutiny is a daily routine. But between January 5-7 2010, the tables were turned, and the critical lens of a five-yearly review was turned upon NCBS itself. The seriousness of the process was reflected in the size of the review panel - nineteen scientists in all - and the fact that sixteen of these had come from some of the best overseas universities and institutes. "The focus of the review was on examining our science and scientific programmes from the ground up and then distilling an institutional perspective", says NCBS Director, Dr K. VijayRaghavan. Three days were set aside for the Review, the main highlights of which were a series of 36 talks - by every faculty member and facility head - and poster sessions that introduced the research of NCBS in greater depth.

Saturday, January 9th, 2010
Starting January 18, 2010, NCBS and IISc will co-host the annual Asia Pacific Bioinformatics Conference. The Asia Pacific Bioinformatics Conference (APBC) series, founded in 2003, is an annual international forum for exploring research, development and applications of Bioinformatics and Computational Biology.

Bioinformatics is the application of data mining techniques to detect patterns in molecular biological information. The basic information can be of many types, e.g. DNA sequence data, the amino acid composition of proteins, and the levels of gene and protein expression in the cell. Since this data is now being collected in vast quantities, often using automated techniques, one of the main challenges of bioinformatics is to develop ever-more powerful computational tools.

Saturday, January 2nd, 2010
For most of us at NCBS, the K. VijayRaghavan we meet on a daily basis is the ever-affable, always approachable and remarkably visionary leader of the Centre.
Saturday, January 2nd, 2010
For three days during the second weekend of January, seventy five scientists from different laboratories around the world will gather together on the campus of NCBS. Despite their varied research interests and locations, they share one thing in common - an association with Albert Libchaber, currently a Professor at the Rockefeller University in New York, and also a member of the international scientific advisory board at NCBS.
Saturday, January 2nd, 2010
Ms.Meghna Krishnadas and Mr.Nishant Srinivasaiah were awarded the prestigious K.Ullas Karanth-J.Paul Getty Fellowships for 2008-09 recently at the National Centre for Biological Sciences. This Fellowship has been instituted to honor academic performance and out of classroom conservation activities among students of the Masters course in Wildlife Biology and Conservation, offered jointly by the National Centre for Biological Sciences, Centre for Wildlife Studies and Wildlife Conservation Society-India Program.

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