K VijayRaghavan remembers Krishnan

Tuesday, May 27th, 2014
ksk

Krishnan joined the Molecular Biology Unit at TIFR in Colaba first as a Visiting Fellow ( Postdoc) and then was 'absorbed', as the term goes, as a Fellow. He had earlier joined the BARC training school after his Master's from Kerala and if he had stayed at BARC he would have been involved in a very different task. At BARC, he visited TIFR and met with Obaid who suggested that he write to G. N. Ramachandran (GNR) at IISc. GNR invited him to join IISc as his student and Krishnan quit BARC and typically hung around at IISc. Soon, a new lecturer, the young P. Balaram was appointed and GNR told  Krishnan that he would be better off working with Balaram. Krishnan joined Balaram, who was a few years younger than  him and together their work set the stage for Balaram's foray into biophysics that was to be transformative. Krishnan did a brief post-doc, less than a year, at the University of Massachusetts at Amherst, which resulted in a bunch of papers and a patent which made the University a lot of money, though Kits typically did not bother to get his name into the patent. He then joined TIFR. The first few years went by in helping everyone and talking about science. Krishnan crushed flies, extracted membranes and characterised membrane proteins and their function. He went to the Medical Research Council  Laboratory for Molecular Biology in Cambridge for a few months to learn from Mike Wilcox how to make monoclonal  antibodies and set up a superb facility in Bombay, all done with minimum expense, maximum fun and undecipherable conversation. It was, however, clear to all and to Krishnan particularly that he was too smart a person to just pursue  science as a set of minor achievable goals. Yet there was no sign of the excitement of the chase coming from anything that he was doing. The exciting things were all too broad a cloth, and with Krishnan it was also an extraordinarily multi-coloured crazily interwoven tapestry.

The real world of jobs and promotions wanted measurable success. While TIFR was generous enough to wait, time and  patience were running out and Krishnan himself was the one most impatient with himself. Would we again see the Krishnan who so interactively kick-started Balaram's science or was that just a flaw in the plan? This was Krishnan's worry and, characteristically again, he leapt to an answer by going to Howard Nash's lab at the NIH where he pretty much invented the field of the genetics of anaesthesiology. Krishnan had hit upon an answer on how he would pursue his science: He would do what he loved, looking at animals in many ways and while he knew all the details of everything else form molecules to cells to tissues, he would inspire others to get the important details done. Returning to Bombay he worked with Mani Ramaswami (who spent a couple of years at NCBS, then in Bombay, before moving to Dublin). Their long collaboration on screening for suppressors of temperature sensitive mutants was a major contribution to the field of synaptic vesicle biology and put both Mani and Krishnan on the global centre stage. When NCBS moved to Bangalore and Jitu joined, a similar transformative collaboration started in studying the mechanisms of endocytosis. In a visit to Utah to see a friend, Mani met Toto Olivera from the Philippines who was studying the toxins of cone snails. Mani's description of this captivated Krishnan who embarked on the field biology of cone snails in peninsular India. This is phenomenal work whose detailed appreciation must be written. Starting a collaboration with Balaram and colleagues again on the biology of cone toxins was tour de force of modest biology form molecules to the field. This way of working also needs to be written about in detail: This is just the kind of work that India needs. Collaborative, grand, rooted in the environment and yet globally of the highest class. About all this and more soon, but all this wonderful science is really about a wonderful person. We often moan the passing of periods where science was done as in pursuit of curiosity and joy. Krishnan simply showed us how wrong this view is. As long as we pursue scientific questions, there is fun to be had. If we pursue the surrogate markers, the derivatives, the consequences of science, ignoring science itself, then there is only constant envy, whining and bitterness to be had. Krishnan cared two hoots about awards, recognitions and prizes, while enjoying his scientific friends successes in these arenas. They in turn admired him and loved him more than if he had all the awards in the world. Krishnan's love of people, birds, animals (except the slight tension with the 3-legged stray dog of the TIFR  colonnade) and indeed of the planet was a seamless morphing of ideas, fiction, fact, reality and the future. His presence in the lab was reassuring. His advice was deep, unselfish, impossibly complicated at times, but always extraordinary fun.  The suddenness of his departure makes it all seem unreal.

Yet his presence everywhere on the campus and all over India, from Arunachal to Kanyakumari will remain and his style of science will inspire our future.

- K VijayRaghavan

Comments

A great loss. He was a very

A great loss. He was a very friendly and informative man to talk to with some extraordinary passions in life. The sort of person young scientists will miss having around.

I remember him as a soft,

I remember him as a soft, gentle person. my first meeting with him at TIFR is a memorable one and happened to meet him NCBS last year... He is truly nice person.

We knew Dr. K.S.Krishnan from

We knew Dr. K.S.Krishnan from 1973, when he was at BARC at Trombay. He was at that time deciding to do PHD at IISc Bangalore. I was at TIFR/Mumbai working with DR. M.R. Das. He was instrumental in inspiring me to continue my Doctoral Studies at U.Massachusetts at Amherst. We overlapped at Amherst for 6 months with Dr. John F. Brandts. He was good in science as wells as in Electronics and able to repair Microcalorimeter which impressed Dr. John F. Brants and asked Dr. Krishnan to stay for longer period of time. His son Kartik was born at nearby Cooley Dickenson Hospital, Northampton,MA. His wife Chandra Krishnan is also a very loving person. We have had contact with him for so many years and it was revived when he came to NIH for 2 years with Dr. Howard Nash's Lab. Last I met him at NCBS in March of 2012. He was at that time as interested in Biology as he was in 1973 meeting. I got yesterday the e-mail for Dr. Bondada Subbarao while I waiting at O'Hare airport after attending the wedding of another former TIFR colleague Dr Radheshyam Jaiswal's daughter. My wife Lakshmi and I were shocked when we heard of Dr. Krishnan's heart attack. He wanted to go back to Palghat where he grew up and had constructed a house. His devotion to Science one can say lasted the final second of his life. My condolences to Mrs. Chandra Krishnan, his sons Kartik, Anand, his co-brother-n law Dr. and Mrs. Gopal and Raji Gopal. Dr. T.V. Gopal also is a TIFR alumni and like Dr. Krishnan is also BARC training school officer before pursuing his PH.D. It is a great loss for us. Easwara Iyer Sadasivan

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